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1.
Int. j. morphol ; 41(4): 1267-1272, ago. 2023. ilus, tab
Article in English | LILACS | ID: biblio-1514354

ABSTRACT

SUMMARY: In the study, it was aimed to predict sex from hand measurements using machine learning algorithms (MLA). Measurements were made on MR images of 60 men and 60 women. Determined parameters; hand length (HL), palm length (PL), hand width (HW), wrist width (EBG), metacarpal I length (MIL), metacarpal I width (MIW), metacarpal II length (MIIL), metacarpal II width (MIIW), metacarpal III length (MIIL), metacarpal III width (MIIIW), metacarpal IV length (MIVL), metacarpal IV width (MIVW), metacarpal V length (MVL), metacarpal V width (MVW), phalanx I length (PILL), measured as phalanx II length (PIIL), phalanx III length (PIIL), phalanx IV length (PIVL), phalanx V length (PVL). In addition, the hand index (HI) was calculated. Logistic Regression (LR), Random Forest (RF), Linear Discriminant Analysis (LDA), K-nearest neighbour (KNN) and Naive Bayes (NB) were used as MLAs. In the study, the KNN algorithm's Accuracy, SEN, F1 and Specificity ratios were determined as 88 %. In this study using MLA, it is understood that the highest accuracy belongs to the KNN algorithm. Except for the hand's MIIW, MIIIW, MIVW, MVW, HI variables, other variables were statistically significant in terms of sex difference.


En el estudio, el objetivo era predecir el sexo a partir de mediciones manuales utilizando algoritmos de aprendizaje automático (MLA). Las mediciones se realizaron en imágenes de RM de 60 hombres y 60 mujeres. Parámetros determinados; longitud de la mano (HL), longitud de la palma (PL), ancho de la mano (HW), ancho de la muñeca (EBG), longitud del metacarpiano I (MIL), ancho del metacarpiano I (MIW), longitud del metacarpiano II (MIIL), ancho del metacarpiano II (MIIW), longitud del metacarpiano III (MIIL), ancho del metacarpiano III (MIIIW), longitud del metacarpiano IV (MIVL), ancho del metacarpiano IV (MIVW), longitud del metacarpiano V (MVL), ancho del metacarpiano V (MVW), longitud de la falange I (PILL), medido como longitud de la falange II (PIIL), longitud de la falange III (PIIL), longitud de la falange IV (PIVL), longitud de la falange V (PVL). Además, se calculó el índice de la mano (HI). Regresión logística (LR), Random Forest (RF), Análisis discriminante lineal (LDA), K-vecino más cercano (KNN) y Naive Bayes (NB) se utilizaron como MLA. En el estudio, las proporciones de precisión, SEN, F1 y especificidad del algoritmo KNN se determinaron en un 88 %. En este estudio que utiliza MLA, se entiende que la mayor precisión pertenece al algoritmo KNN. Excepto por las variables MIIW, MIIIW, MIVW, MVW, HI de la mano, otras variables fueron estadísticamente significativas en términos de diferencia de sexo.


Subject(s)
Humans , Male , Female , Carpal Bones/diagnostic imaging , Finger Phalanges/diagnostic imaging , Metacarpal Bones/diagnostic imaging , Sex Determination by Skeleton/methods , Algorithms , Magnetic Resonance Imaging , Carpal Bones/anatomy & histology , Discriminant Analysis , Logistic Models , Finger Phalanges/anatomy & histology , Metacarpal Bones/anatomy & histology , Machine Learning , Random Forest
2.
Gac. méd. espirit ; 24(3): [8], dic. 2022.
Article in Spanish | LILACS | ID: biblio-1440159

ABSTRACT

Fundamento: Las infecciones del sistema nervioso central constituyen una importante causa de morbilidad y mortalidad neurológica. La púrpura fulminante o meningococemia es una enfermedad grave que evoluciona a severas complicaciones y secuelas, sin embargo, es infrecuente que ocurra momificación o amputación natural de los dedos de las manos y los pies. Objetivo: Describir el caso de un paciente con meningococemia fulminante, al cual se le momificaron de manera natural las falanges de las manos y los pies como consecuencia de la enfermedad. Presentación del caso: Se presenta un paciente de 18 años de edad que fue diagnosticado con meningococemia. Clínicamente presentó fiebre, cefalea intensa, lesiones purpúrico hemorrágicas, petequias y hematomas en piel, evolutivamente shock séptico y disfunción múltiple de órganos. Posterior a 16 días de estadía en sala egresó vivo del hospital, pero con secuelas caracterizadas por momificación de las falanges de las manos y los pies. Conclusiones: La meningococemia es una enfermedad aguda, potencialmente mortal y se reporta mayormente en la edad pediátrica. Entre los sobrevivientes es infrecuente que ocurra la momificación de las falanges de las manos y los pies, como ocurrió en el caso reportado.


Background: Infections of the central nervous system are a significant cause of neurological morbidity and mortality. Purpura fulminans or meningococcemia is a serious disease that evolves into severe complications and sequelae, however it is infrequent for mummification or natural amputation of fingers and toes to occur. Objective: To describe the case of a patient with fulminant meningococcemia, in whom hands and feet phalanges were naturally mummified as a consequence of the disease. Case report: An 18-year-old patient diagnosed with meningococcemia is presented. Clinically, he presented fever, intense headache, purpuric hemorrhagic lesions, petechiae and bruises on the skin, progressively septic shock and multiple organ dysfunction. After 16 days in hospital, he was discharged alive, but with some sequelae characterized by mummification of the hands and feet phalanges. Conclusions: Meningococcemia is an acute, life-threatening disease and is mostly reported in the pediatric age. Mummification of the hands and feet phalanges is uncommon among survivors, as occurred in the reported case.


Subject(s)
Toe Phalanges , Finger Phalanges , Meningococcal Infections
3.
China Journal of Orthopaedics and Traumatology ; (12): 1189-1192, 2022.
Article in Chinese | WPRIM | ID: wpr-970806

ABSTRACT

OBJECTIVE@#To explore clinical efficacy of external placement of micro-locking plate combined with small incision reduction in treating proximal phalanx comminuted fractures.@*METHODS@#From January 2018 to December 2019, 17 patients with proximal phalanx comminuted fractures were treated with micro-locking plate combined with small incision open reduction, including 13 males and 4 females, aged from 16 to 64 years old with an average of (37.2±20.1) years old. Two patients were accompanied by soft tissue extrusion and opening injuries, which were treated with fixed treatment after the first-stage emergency debridement. Curative effect was evaluated according to total active flexion scale (TAFS) of American Hand Surgery Association at 6 months after operation;and fracture healing, nailing, local soft tissue healing, complications were observed.@*RESULTS@#All patients were followed up from 6 to 12 months with an avaerge of(9.3±3.6) months. Two patients occurred delayed union, 1 occurred local skin necrosis and was treated with the second-stage skin grafting to repair wound surface. No external screw breakage or infection was reported, skin soft tissue healed favorably and reached bony union, the union time from 12 to 24 weeks with an average of (15.7±2.1) weeks. According to TAFS standard, 9 patients got excellent result, 5 good and 3 poor at 6 months after operation.@*CONCLUSION@#External micro-locking plate combined with small incision reduction in treating proximal phalanx comminuted fracture, which has advantages of good condition of skin and soft tissue, simple operation, early functional exercise, good range of motion of interphalanx joint, and function score of recovery period is high.


Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Bone Plates , External Fixators , Fracture Fixation , Fracture Healing , Fractures, Comminuted/surgery , Treatment Outcome , Finger Phalanges/surgery
4.
Int. j. morphol ; 39(6): 1727-1730, dic. 2021. ilus, tab, graf
Article in English | LILACS | ID: biblio-1385526

ABSTRACT

SUMMARY: Analysis and systematization of the longitudinal dimensions of the phalanges of the index and ring fingers for the classification of morphological types of the hand using classification and regression trees (CART). X-rays of the hands of 50 men and 50 women (mean age 47.16 (10.1) years, range 23-65 years) were studied. Each hand, depending on the ratio of the length of the index and ring fingers, was classified into three types: radial (R, 2d>4d), indefinite (N, 2d=4d), ulnar (U, 2d>4d). Morphometry of radiographs included measurements of the lengths of the proximal (PP), middle (MP), and distal (DP) phalanges. The sex differences of the analyzed indicators are statistically significant. There were no significant bilateral differences between the phalanges of the II and IV fingers in length, regardless of sex (p>0.05). A set of rules for classifying the morphological types of the hand depending on the lengths of the phalanges of the index and ring fingers was created by constructing a binary decision tree. The CART method demonstrates the usefulness of this statistical procedure for developing a scientifically based prediction of the morphological type of the hand. The results of this study can be the basis of an algorithm for determining the morphological type of the hand depending on the length of the phalanges of the fingers.


RESUMEN: En este estudio se realizó un análisis y sistematización de las dimensiones longitudinales de las falanges de los dedos índice y anular para la clasificación de tipos morfológicos de la mano, mediante árboles de clasificación y regresión (CART). Se estudiaron radiografías de las manos de 50 hombres y 50 mujeres (edad media 47,16 (10,1) años, rango 23-65 años). Cada mano, según la proporción de la longitud de los dedos índice y anular, se clasificó en tres tipos: radial (R, 2d> 4d), indefinida (N, 2d = 4d), ulnar (U, 2d> 4d). La morfometría de las radiografías incluyó mediciones de las longitudes de las falanges proximal (FP), media (FM) y distal (FD). Las diferencias de sexo de los indicadores analizados fueron estadísticamente significativas. No hubo diferencias bilaterales significativas entre las falanges de los dedos II y IV en longitud, independientemente del sexo (p> 0,05). Se creó un conjunto de reglas para clasificar los tipos morfológicos de la mano en función de las longitudes de las falanges de los dedos índice y anular mediante la construcción de un árbol de decisión binario. El método CART demuestra la utilidad de este procedimiento estadístico para desarrollar una predicción con base científica del tipo morfológico de la mano. Los resultados de este estudio pueden ser la base de un algoritmo para determinar el tipo morfológico de la mano en función de la longitud de las falanges de los dedos.


Subject(s)
Humans , Male , Female , Finger Phalanges/diagnostic imaging , Hand/diagnostic imaging , Logistic Models , Classification , Finger Phalanges/anatomy & histology , Hand/anatomy & histology
5.
Rev. Asoc. Argent. Ortop. Traumatol ; 85(4): 335-348, dic. 2020.
Article in Spanish | LILACS, BINACIS | ID: biblio-1351409

ABSTRACT

Introducción: El osteoma osteoide de falange es un cuadro infrecuente. El objetivo de este artículo es presentar cinco pacientes con diagnóstico histopatológico de osteoma osteoide de falange y resaltar los aspectos más relevantes del diagnóstico y el tratamiento. Materiales y Métodos: Estudio descriptivo, retrospectivo. Se evaluaron el dolor, según la escala analógica visual, la movilidad activa y el puntaje QuickDASH antes de la cirugía y en el control final a los 35.4 meses. Resultados: El tiempo medio desde la primera consulta hasta el diagnóstico fue de 10.6 meses (rango 5-16). El puntaje QuickDASH medio preoperatorio fue de 22,72 (rango 6,8-40,9). Luego del seguimiento medio de 35.4 meses (rango 17-63), todos los pacientes estaban satisfechos con el resultado. El puntaje medio de dolor fue 0. El puntaje QuickDASH medio fue 0. Conclusiones: El osteoma osteoide debe pensarse como diagnóstico diferencial ante un paciente que consulta por dolor digital subagudo o crónico que cede con antinflamatorios no esteroides. El tratamiento quirúrgico mediante el curetaje simple o la resección en bloque logra resultados satisfactorios. Sin embargo, como su prevalencia es baja, se suele pasar por alto y así se retrasan el diagnóstico y el tratamiento. Nivel de Evidencia; IV


Introduction: Osteoid osteomas are rarely found in the phalanges. The purpose of this study is to report 5 cases with histologic diagnosis of phalanx osteoid osteoma and highlight the most important aspects of its diagnosis and treatment. Materials and Methods: A descriptive, retrospective study was conducted. Evaluation included pain level using the visual analog scale (VAS), active range of motion, and QuickDASH score before surgery and at final follow-up (mean, 35.4 months). Results: The mean time from first consultation to diagnosis was 10.6 months (range, 5-16 months). The mean preoperative QuickDASH score was 22.72 (range, 6.8-40.9). At last follow-up (mean, 35.4 months; range, 17-63), all patients were satisfied with the outcome. The mean VAS score for pain was 0. The mean QuickDASH score was 0. Conclusions: Osteoid osteoma should be considered in the differential diagnosis when patients complain of subacute or chronic digital pain that improves with NSAIDs. Surgical treatment by simple curettage or en bloc resection shows satisfactory results. However, due to its low prevalence, osteoid osteoma is commonly underdiagnosed resulting in diagnosis and treatment delays. Level of Evidence; IV


Subject(s)
Adolescent , Young Adult , Osteoma, Osteoid , Pain , Finger Phalanges/surgery , Finger Joint
6.
Rev. Asoc. Argent. Ortop. Traumatol ; 85(2): 125-132, jun. 2020.
Article in Spanish | BINACIS, LILACS | ID: biblio-1125549

ABSTRACT

Objetivo: Evaluar los resultados y las complicaciones de una serie de pacientes con consolidación viciosa de falange. Materiales y Métodos: Se realizó un estudio retrospectivo que incluyó a pacientes con consolidación viciosa de falange tratados mediante osteotomía en el sitio de la deformidad, estabilizados con osteosíntesis rígida. Se registró la movilidad de los dedos. La valoración subjetiva consistió en el puntaje DASH y una escala analógica visual para el dolor en reposo, en actividad y la función. Resultados: Doce pacientes (13 falanges) cumplieron los criterios de inclusión. El tiempo promedio entre la lesión inicial y la osteotomía fue 14 meses y el seguimiento promedio, 34 meses. La movilidad final promedio en flexo-extensión fue 89° metacarpofalángica, 74° interfalángica proximal, 54° interfalángica distal y la distancia pulpejo-palma, 3 mm. El puntaje promedio de la escala analógica visual en reposo fue 0; en actividad, 1 y la función promedio fue de 7 puntos; el puntaje DASH promedio fue 6. No hubo casos de seudoartrosis. Cinco pacientes requirieron el retiro de la placa. Los pacientes con osteotomía articular no presentaron signos de artrosis. Conclusiones: La osteotomía de falange en el sitio de la deformidad es un procedimiento eficaz con un buen resultado objetivo y subjetivo a corto plazo. La utilización de placas y tornillos conlleva una tasa más alta de complicaciones; por lo tanto, los pacientes deben ser advertidos sobre la posibilidad de una segunda intervención quirúrgica. Nivel de Evidencia: IV


Objective: To present the results and complications of a series of phalangeal malunion patients. Materials and Methods: A retrospective study was conducted on phalangeal malunion patients treated with an osteotomy at the deformity site and stabilized with rigid internal fixation. Postoperative mobility of the digit was recorded. The subjective assessment used the Disabilities of the Arm, Shoulder and Hand (DASH) score and a Visual Analogue Scale (VAS) to rate their function and pain at rest and during activity. Results: Twelve patients (13 phalanges) met the inclusion criteria. The average time between fracture and osteotomy was 14 months and the mean follow-up was 34 months. Final mobility in flexo-extension was: 89 degrees for metacarpophalangeal joint, 74 degrees proximal interphalangeal joint, 54 degrees distal interphalangeal joint. The average VAS pain score was 0 at rest and 1 during activity, and the average function was 7 points. The average DASH score was 6. There were no cases of nonunion. Five patients required plate removal. No patients with articular osteotomy presented signs of Osteoarthritis. Conclusions: Phalangeal osteotomy at the deformity site is an effective procedure with good objective and subjective short-term outcomes. Patients should be warned about the possibility of a second procedure in cases of plate fixation due to a higher complication rate associated with plate and screw fixations. Level of Evidence: IV


Subject(s)
Adult , Middle Aged , Osteotomy , Treatment Outcome , Fractures, Malunited , Finger Phalanges/surgery , Fracture Fixation, Internal
7.
Rev. Asoc. Argent. Ortop. Traumatol ; 85(Supl. de Asociación Argentina de Cirugía de la Mano): S2-S11, 2020.
Article in Spanish | LILACS, BINACIS | ID: biblio-1352418

ABSTRACT

Objetivos: Evaluar los resultados clínicos y radiográficos de pacientes con fracturas extrarticulares de falanges y metacarpianos de la mano, tratados mediante osteosíntesis mininvasiva con tornillos endomedulares compresivos retrógrados.materiales y métodos: Estudio prospectivo que incluyó a pacientes >18 años con fracturas cerradas transversales u oblicuas cortas, ex-trarticulares, de falanges y metacarpianos tratadas entre noviembre de 2016 y junio de 2019. La serie estaba integrada por 47 pacientes, con 76 fracturas (28 de metacarpianos, 27 de falange proximal y 21 de falange media). Se evaluaron los resultados clínicos y funcionales con goniometría, registrando el rango de movilidad activa total. La evaluación radiográfica se realizó sobre la base de los criterios establecidos por Pun y cols. Todos los pacientes completaron el cuestionario QuickDASH en el examen final. Resultados: El tiempo promedio de seguimiento fue de 24.5 meses. El rango de movilidad activa total promedio fue de 238° para todas las fracturas, 252° para las de metacarpianos y 230° para las de falanges. Se observó la consolidación radiográfica de todas las fracturas. El tiempo promedio de retorno a la actividad habitual fue de 79 días. El resultado final del cuestionario QuickDASH fue 4,5. No hubo complicaciones ni cirugías secundarias. Conclusiones: La osteosíntesis mininvasiva con tornillos endomedulares compresivos retrógrados resultó una alternativa eficaz para el tratamiento de fracturas extrarticulares de falanges y metacarpianos. Nivel de Evidencia: II


Objective: To study the clinical and radiological outcomes of patients with extra-articular phalangeal and metacarpal fractures who were treated with minimally invasive internal fixation using retrograde intramedullary compression screws.materials and me-thods: Prospective study in patients over 18 years of age treated for simple, transverse or short oblique, extra-articular phalangeal and metacarpal fractures between November 2016 and June 2019. The series included 47 patients and 76 fractures: 28 metacar-pal bones (MC), 27 proximal phalanges (PP), 21 middle phalanges (MP). Clinical and functional outcomes were assessed with goniometry, documenting the total active range of motion (TAM). Radiological outcomes were assessed using the criteria proposed by Pun et al. All patients completed the Quick DASH questionnaire at last follow-up. Results: The average follow-up period was 24.5 months. All study fractures average TAM was 238°, metacarpal TAM was 252°, and phalangeal TAM was 230°. Radiograph evaluation showed fracture consolidation in all cases. Average time taken to return to normal daily activities was 79 days. Average final Quick DASH score was 4.5. There were no complications nor secondary surgeries. Conclusions: Minimally invasive internal fixation with retrograde intramedullary compression screw proved to be a highly effective option in the treatment of extra-articular phalangeal and metacarpal fractures. Level of Evidence: II


Subject(s)
Finger Phalanges/injuries , Metacarpal Bones/injuries , Fractures, Bone , Hand Injuries
8.
Rev. bras. ortop ; 54(3): 335-338, May-June 2019. graf
Article in English | LILACS | ID: biblio-1013725

ABSTRACT

Abstract Florid reactive periostitis is a benign andrare lesion that is a recurrent diagnostic problem. Its etiopathogenesis remains unknown. Florid reactive periostitis consists of a fibrotic, cartilage- producing tumor accompanied by an aggressive inflammatory periosteal and soft tissue reaction. It typically occurs in adolescents and young adults, mostly female; it often affects hand and foot bones, and it may occur in long bones. Its diagnosis remains a major challenge due to the vast possibility of differential diagnoses. Therefore, careful clinical, radiological, and pathological evaluation is required to establish a proper diagnosis. We report the case of a patientwith florid reactive periostitis in the proximal phalanx of the right index finger, who underwent surgical excision with a wide margin, from the second ray to the proximal third of the secondmetacarpal bone, and evolved without complications,with satisfactory range of motion and strength.


Resumo A periostite reativa florida éumalesão benigna e rara que constitui umproblema recorrente de diagnóstico. Sua etiopatogênese permanece desconhecida. A periostite reativa florida caracteriza- se por ser uma reação periosteal agressiva e inflamatória de tecido mole e por ser um tumor portador de fibrose e produtor de cartilagem. Ocorreemadolescentes e adultos jovens, com predomínio no sexo feminino, e acomete com frequência os ossos das mãos e pés, podendoacometer tambémossos longos.Odiagnósticopermaneceumgrandedesafiodevido à enorme possibilidade de diagnósticos diferenciais. Por isso, uma cuidadosa avaliação clínica, radiológica e patológica é necessária para fechar o diagnóstico. Relata-se o caso de umpaciente com periostite reativa florida na falange proximal do segundo dedo da mão direita, que foi submetida à excisão cirúrgica com margem ampla do segundo raio até o terço proximal do segundometacarpo, e evoluiu semqueixas, comamplitude demovimento e força satisfatória.


Subject(s)
Humans , Female , Adolescent , Periostitis , Bone Neoplasms , Finger Phalanges
12.
Med. interna (Caracas) ; 35(4): 131-131, 2019. ilus
Article in Spanish | LIVECS, LILACS | ID: biblio-1102275
13.
Rev. Asoc. Argent. Ortop. Traumatol ; 83(3): 179-187, set. 2018. []
Article in Spanish | LILACS, BINACIS | ID: biblio-976768

ABSTRACT

Introducción: Se realizo un estudio de cohorte prospectivo para evaluar los resultados funcionales de pacientes laborales con fracturas de falange tratadas mediante placas y establecer factores de mal pronostico. Materiales y Métodos: Desde mayo de 2012 hasta mayo de 2014, 55 pacientes laborales con fracturas de falange fueron operados consecutivamente, mediante reduccion y osteosintesis con placa y tornillos. Cuarenta y dos (39 hombres, edad promedio 30.76 anos) fueron evaluados, con 68 falanges operadas (primera falange 15, segunda falange 53). El 28% de las fracturas fueron expuestas; el 38,24%, conminutas y el 11,76% tenia compromiso articular. El seguimiento promedio fue de 3.38 meses. Resultados: Se logro la consolidacion osea de todas las fracturas a los 1.8 meses. La movilidad para el pulgar (Gingrass) fue buena en dos casos y regular en uno. En los restantes dedos (Belsky), fue excelente (35%), buena (55%) y mala (9%). El puntaje DASH promedio fue de 18,53. Se observaron peores resultados en las fracturas de la primera falange respecto de la segunda falange y en pacientes con mas edad que en los mas jovenes, ambos con significancia estadistica. No hubo relacion entre el resultado y las demas variables estudiadas. Cuatro pacientes tuvieron complicaciones (9,5%). Conclusiones: Al comparar nuestra serie con otras publicadas, hubo menos complicaciones y los resultados fueron similares, pero a diferencia de otros autores, no acostumbramos a retirar el material ni a realizar tenolisis ni artrolisis. Se logro la consolidacion osea en todos los casos y los resultados fueron satisfactorios en el 90% de los pacientes. Nivel de Evidencia: IV


Introduction: A prospective cohort study was carried out to evaluate functional results in workers with phalangeal fractures treated with plates and to establish poor prognostic factors. Methods: From May 2012 to May 2014, 55 workers with phalangeal fractures were operated on consecutively by reduction and fixation with plate and screws. Forty-two patients (39 men; average age 30.76 years) were evaluated, with 68 operated phalanges (first phalanx 15, second phalanx 53). Twenty-eight percent of fractures were open, 38.24% comminuted and 11.76% had joint involvement. Average follow-up: 3.38 months. Results: Bone union was achieved in all fractures in 1.8 months. Gingrass score for the thumb was good in two cases and regular in one. In the remaining fingers, Belsky score was excellent (35%), good (55%), and poor (9%). Average DASH score was 18.53. Worse results were observed in the first phalanx fractures with respect to the second and in older patients than in the younger, both with statistical significance. No relationship was observed among the outcome and other variables studied. Four patients had complications (9.5%). Conclusions: When comparing our findings with other studies, the rate of complications was small, and similar results were obtained, but unlike other authors, we are not used to removing hardware with tenolysis or arthrolysis. Bone union was achieved in all cases and results were satisfactory in 90% of patients. Level of Evidence: IV


Subject(s)
Adult , Bone Plates , Finger Phalanges/surgery , Finger Phalanges/injuries , Fractures, Bone/surgery , Fracture Fixation, Internal/methods , Treatment Outcome
14.
Pakistan Journal of Medical Sciences. 2018; 34 (1): 82-87
in English | IMEMR | ID: emr-151152

ABSTRACT

Objectives: Brachdactyly a genetic disorder associated with the abnormal development of metacarpals, phalanges or both which results in the shortening of hands and feet. Mutations in the contributing genes has been recognized with the majority of the investigated syndromic form of brachdactyly. The current study was proposed to examine mutation in NOG and GDF5 genes in a Pakistani family


Methods: Poly Acrylamide Gel Electrophoresis and Polymerase Chain Reaction was used for the genomic screening and linkage analysis to observe the mutation in genes. The samples were collected from Luckki Marwat district, KPK, while the research study was conducted in the department of Biochemistry, Quaid-IAzam University, Islamabad, Pakistan


Results: After survey, family was identified with brachdactyly type A2 and investigated a heterozygous arginine to glutamine exchange in the growth demarcation factor 5 in all the victim persons. Different types of skeletal dysplasia resulted due to mutation in the GDF5 genes. Novel GDF5 genes mutations were reported with distinct limb malformation and sequencing of coding region revealed that the mildly affected individuals were heterozygous while the harshly affected individuals were homozygous


Conclusion: The current study reported the genetic variability and concluded that the Brachdacytyly type A2 and type B2 resulted due to mutation in GDF5 and NOG genes respectively. A new subtype of brachydactyly [BDB2] was instigated as a result of novel mutations in NOG. The mutation has been reported for the first time in Pakistani population and especially in Pushtoon ethnic population


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Mutation , Genotype , Finger Phalanges/abnormalities , Pedigree , Genetic Linkage , Polymerase Chain Reaction , Electrophoresis, Polyacrylamide Gel , Growth Differentiation Factor 5 , Carrier Proteins
16.
Journal of the Korean Fracture Society ; : 61-70, 2018.
Article in Korean | WPRIM | ID: wpr-738430

ABSTRACT

Hand fractures are the second most common fracture in the upper extremities after the distal radius, and patients with these injuries may be experienced in hand surgery clinics. On the other hand, during the treatment of hand fractures, complications can occur due to complex functions of the hand and small-sized injuries to the bone and soft tissues. This review focused on the principles of management of these fractures, including injury mechanism, evaluations and recent treatment options. Minimally invasive surgery in various types of hand fractures, including the phalanx and metacarpal bone, is preferred because early mobilization after surgery has been emphasized to reduce complications, such as stiffness.


Subject(s)
Humans , Early Ambulation , Finger Phalanges , Hand , Metacarpal Bones , Minimally Invasive Surgical Procedures , Radius , Upper Extremity
17.
Rev. bras. ortop ; 52(6): 685-692, Nov.-Dec. 2017. tab, graf
Article in English | LILACS | ID: biblio-899202

ABSTRACT

ABSTRACT OBJECTIVE: Report the results of treatment of fingertip injuries and describe this reproducible and low cost surgical technique, which utilizes a polypropylene prosthesis that temporarily replaces the nail and is placed on the area of injury, providing protection and encouragement for healing by secondary intention. METHOD: This study evaluated 22 patients with traumatic injuries of the fingertips in the period from January 2012 to December 2015. All procedures were performed by the same surgeon. The mean postoperative follow-up was 13 months, with a minimum follow-up of six months. For all statistical inferences, a p-value of 0.05 was considered. The software used was SPSS version 21.0 for Windows. RESULTS: There were no cases of complications related to the polypropylene device. There was no significant difference between static two-point discrimination and age, between discrimination and time between injury and surgery, or between discrimination and time to follow-up. The authors used a table of scores that includes three factors proposed by Jefferson for a better evaluation of the results. 72.7% (16 cases) of patients had good results, 22.7% (five cases) fair results, and only 4.5% (one case) poor result. CONCLUSION: This study presented a new technique for finger tip lesions, simple and easily reproducible, with satisfactory results and low complication rates.


RESUMO OBJETIVO: Relatar os resultados do tratamento das lesões de ponta de dedo, bem como descrever a técnica cirúrgica, reprodutível e de baixo custo, que usa uma prótese de polipropileno que substitui temporariamente a unha e é colocada sobre a área da lesão, promove proteção e estímulo para a sua cicatrização por segunda intenção. MÉTODO: Foram avaliados 22 pacientes portadores de lesões traumáticas da polpa digital de janeiro de 2012 a dezembro de 2015. Todos os procedimentos foram feitos pelo mesmo cirurgião. O tempo médio de seguimento pós-operatório foi de 13 meses, com um seguimento mínimo de seis meses. Para toda a inferência estatística, considerou-se um valor de p de 0,05. O software usado foi o SPSS for Windows, versão 21.0. RESULTADOS: Não foi observado caso de complicação referente ao dispositivo de polipropileno. Não foi observada diferença estatística significante entre sensibilidade estática entre dois pontos (DE2P) e idade, entre sensibilidade e tempo entre lesão e data da cirurgia nem entre sensibilidade e tempo de seguimento. Adotou-se uma tabela de escores que incluiu três fatores propostos por Jefferson para melhor avaliação dos resultados; 72,7% (16 casos) dos pacientes tiveram resultados bons, 22,7% (cinco) regulares e apenas 4,5% (um) apresentou resultado ruim. CONCLUSÃO: O presente estudo apresentou uma nova técnica, simples e facilmente reprodutível, para as lesões das pontas de dedos com resultados satisfatórios e baixa taxa de complicações.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Finger Phalanges , Fingers/surgery , Polypropylenes , Prostheses and Implants
18.
Rev. paul. pediatr ; 35(4): 436-442, out.-dez. 2017. tab
Article in Portuguese | LILACS | ID: biblio-902869

ABSTRACT

RESUMO Objetivo: Avaliar a massa óssea pela ultrassonografia quantitativa de falanges em jovens praticantes de karatê em relação a um grupo controle. Métodos: Amostra constituída por 162 praticantes de karatê (52 meninas) e 326 controles escolares (110 meninas) saudáveis, de 6 a 16 anos de idade, do oeste do Paraná. Foram avaliados peso, estatura, índice de massa corporal (IMC), Amplitude Dependent Speed of Sound (AD-SoS) e Bone Time Transmission (BTT), e os valores de IMC, AD-SoS e BTT transformados em escore Z. Aplicaram-se testes de Mann-Whitney, qui-quadrado ou Exato de Fisher e regressão linear múltipla, sendo significante p≤0,05. Resultados: Para ambos os sexos, os praticantes de karatê apresentaram valores superiores do escore Z do BTT comparados aos controles. Quanto à AD-SoS, as meninas do grupo de controle apresentaram valor absoluto e de escore Z superiores aos apresentados pelas praticantes de karatê do mesmo sexo. Ao avaliar a frequência relativa e absoluta de acordo com o escore Z do BTT em ambos os grupos, os meninos praticantes de karatê apresentaram maior frequência de massa óssea adequada. Nas meninas praticantes de karatê, a idade apresentou poder de explicação de 42% na variação da AD-SoS e o peso de 45% na variação do BTT. Nos meninos praticantes de karatê, a idade apresentou poder de explicação de 26% na variação da AD-SoS e a estatura 36% na variação do BTT. Conclusões: Nesse grupo de crianças e adolescentes, independentemente do sexo, os praticantes de karatê apresentaram maior massa óssea em relação ao grupo controle, sendo o BTT mais sensível para essa avaliação.


ABSTRACT Objective: To evaluate bone mass by quantitative ultrasound of the phalanges in young karate practitioners compared to a control group. Methods: Sample composed of 162 karate practitioners (52 females) and 326 healthy controls (110 females) aged 6 to 16 years old, in Western Paraná (Southern Brazil). Weight, height, BMI, amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT) were evaluated. BMI, AD-SoS and BTT values were converted to Z scores. Mann-Whitney, chi-square or Fisher Exact tests and multiple linear regression were applied, with significance level set at p≤0.05. Results: Both genders showed higher values of BTT as Z scores when compared to control group. Females from the control group had higher AD-SoS values (m/s and Z score) compared to female karate practitioners. When relative and absolute frequencies were assessed according to BTT Z score in both groups, male karate practitioners' bone mass was shown to be adequate more frequently. In female practitioners, age and weight were independent predictors of AD-SoS (R2=0.42) and BTT (R2=0.45), respectively. Among male karate practitioners, age was related to 26% of AD-SoS variances and height was responsible for 36% of BTT variances. Conclusions: Children and adolescents who practice karate were shown to have more bone mass in comparison to the control group, regardless of gender. BTT was more sensitive for this evaluation.


Subject(s)
Humans , Male , Female , Child , Adolescent , Bone Density , Martial Arts , Ultrasonography , Finger Phalanges/diagnostic imaging , Case-Control Studies , Cross-Sectional Studies
19.
Rev. cuba. ortop. traumatol ; 31(2): 1-13, jul.-dic. 2017. ilus, tab
Article in Spanish | LILACS, CUMED | ID: biblio-960645

ABSTRACT

Introducción: La tendovaginitis estenosante de los dedos de la mano o dedo en resorte es una patología relativamente frecuente que puede afectar a personas durante su vida laboral. Existen diversos métodos para solucionar esta afección. Objetivo: Evaluar el empleo durante ocho años de la vaginotomía percutánea en la tendovaginitis estenosante de los dedos largos de las manos. Métodos: Se realizó un estudio de intervención longitudinal prospectivo con adultos mayores de 65 años de edad. La muestra estuvo constituida por 468 pacientes diagnosticados con tendovaginitis estenosante (dedo en resorte). Fueron intervenidos quirúrgicamente 532 dedos con la vagotomía percutánea entre el 1 de enero de 2008 y el 31 de octubre de 2015, en el Centro de Investigaciones en Longevidad, Envejecimiento y Salud. Se evaluaron los pacientes seis meses después del tratamiento. Las variables empleadas fueron: edad, sexo, tiempo de padecimiento, dedo afectado, tiempo quirúrgico, complicaciones perioperatorias, duración del dolor. Se utilizó la clasificación de Newport según el cuadro clínico y el método de Strickland para evaluar los resultados. Resultado: Hubo un predomino del sexo femenino en la sexta década de vida. Las mayores incidencias estuvieron en la mano dominante. Se obtuvo un 98,3 por ciento de resultados satisfactorios. Los tiempos promedios de las variables descritas fueron significativamente cortos. No se mostraron complicaciones serias. Los dedos más afectados fueron el cuarto y el tercero. Hubo predominio de los estadios II y III. Conclusión: La vaginotomía percutánea solucionó satisfactoriamente la morbilidad que produce el dedo en resorte(AU)


Introduction: Stenosing tendovaginitis of hand fingers or spring finger is a relatively frequent pathology that can affect people during their working life. There are several methods to solve this condition. Objective: To evaluate the used of percutaneous vaginotomy in stenosing tendovaginitis of the long fingers for eight years. Methods: A prospective longitudinal intervention was conducted with adults over 65 years of age. 468 patients formed the sample. They were diagnosed with stenosing tendovaginitis (spring finger). Surgery was performed on 532 fingers with percutaneous vagotomy from January 1, 2008 to October 31, 2015, at the Research Center on Longevity, Aging and Health. Patients were assessed six months after treatment. The variables used were age, sex, time of suffering, affected finger, surgical time, perioperative complications, and duration of pain. Newport classification was used according to the symptoms and Strickland method to assess the results. Result: There was predominance of the female sex in their sixth decade of life. The highest incidences were in the dominant hand. Satisfactory results were 98.3 percent. The average times of the variables described were significantly short. No serious complications were shown. The most affected fingers were the fourth and the third. There was predominance of stages II and III. Conclusion: Percutaneous vaginotomy satisfactorily resolved the morbidity produced by the spring finger(AU)


Introduction: La ténosynovite sténosante des doigts de la main, ou doigt à ressort, est une pathologie assez fréquente pouvant affecter les personnes tout au long de leur vie. Il y a plusieurs méthodes pour corriger cette affection. Objectif: Évaluer l'utilisation pendant huit ans de la ténotomie percutanée pour corriger la ténosynovite sténosante des doigts longs de la main. Méthodes: Une étude interventionnelle, longitudinale et prospective des personnes âgées de plus de 65 ans a été effectuée. L'échantillon a été composée de 468 patients diagnostiqués de ténosynovite sténosante (doigt à ressort). Un nombre significatif d'interventions chirurgicales (532 doigts) ont été effectuées entre le 1 janvier 2008 et le 31 octobre 2015 au Centre de recherches sur la longévité, le vieillissement et la santé. Les patients ont été évalués six mois après le traitement. On a utilisé des variables telles que l'âge, le sexe, la durée de l'affection, le doigt affecté, le temps chirurgical, les complications péri-opératoires, et la durée de la douleur. Afin d'évaluer les résultats, on a appliqué la classification de Newport, selon le tableau clinique et la méthode de Strickland. Résultats: On a trouvé que les femmes dans les soixante ans étaient les plus souvent touchées par cette affection, étant la main dominante la plus affectée. Il y a eu de très bons résultats (98.3 pourcent). Les temps moyens des variables décrites ont été notamment courts. Il n'y a pas eu de complications graves. Le troisième et le quatrième doigt ont été les plus fréquemment touchés. Dans la classification, le stade II et III ont été en prédominance. Conclusions: La ténotomie percutanée a réussi à corriger de manière satisfaisante la morbidité provoquée par le doigt à ressort(AU)


Subject(s)
Humans , Male , Female , Aged , Vagotomy/methods , Finger Phalanges/surgery , Tendon Entrapment/surgery , Longitudinal Studies
20.
Rev. colomb. reumatol ; 24(1): 32-39, ene.-mar. 2017. tab, graf
Article in Spanish | LILACS | ID: biblio-900849

ABSTRACT

RESUMEN Objetivo: Determinar en radiografía simple los hallazgos anormales del penacho de la falange distal de los dedos de la mano (PFDM) asociados a la artritis reumatoide (AR) en adultos. Métodos: Se desarrolló una revisión sistemática siguiendo los parámetros de las guías PRISMA en las bases de datos: Medline, Embase, Bireme, Scielo, Google Scholar, entre otras, incluyendo como resultados primarios las alteraciones del PFDM (erosiones, resorción, esclerosis y proliferación) detectadas por radiografía simple en adultos con AR. La prevalencia de los hallazgos radiográficos fue sintetizada usando el modelo de efectos fijos de Mantel-Haenszel. Las asociaciones estadísticas (según el tipo de estudio) se expresaron en términos de riesgo relativo (RR) u odds ratio (OR), con sus respectivos intervalos de confianza y valores p. Resultados: Nueve estudios observacionales fueron incluidos; la prevalencia de esclerosis del PFDM fue del 28,3% (IC 95%: 0,23-0,34; p< 0,001), y un valor I2 = 75%. De otro lado, la prevalencia de resorción del PFDM fue del 1,8% (IC 95%: 0,006-0,05; p < 0,001), con un I2 = 0%. Ningún estudio reportó proliferación o erosiones del PFDM. Conclusiones: La esclerosis del PFDM es la alteración radiográfica más frecuente de esta zona en pacientes con AR, sin embargo, no constituye un hallazgo patognomónico de esta entidad, por tanto, nuevos estudios con mayor solidez metodológica son necesarios para esclarecer esta asociación. Finalmente, la proliferación, erosiones o resorción del PFDM no son lesiones radiográficas típicas de individuos con AR.


ABSTRACT Objective: To determine the abnormal findings in the distal phalanx tuft of the hands (DPTH) in plain radiographs associated with the presence of rheumatoid arthritis (RA) in adults subjects. Methods: A systematic review was performed following the PRISMA guidelines using databases, such as, Medline, Embase, Bireme, Scielo, and Google Scholar. The main changes in the DPTH included erosion, resorption, sclerosis, and proliferation detected on plain radiographs in adults with RA. Prevalence of radiographic findings was analysed using a Mantel-Haenszel fixed effects model. Statistical associations (according to study type) were expressed as relative risk (RR) or odds ratio (OR) with their respective confidence intervals (CI) and p values. Results: A total of 9 studies were included, in which sclerosis prevalence in the DPTH was 28.3% (95% CI: 0.23-0.34; P<.001, and I2 value = 75%). Resorption prevalence in the DPTH was 1.8% (95% CI: 0.006-0.05; P<.001, and I2 value = 0%). No study reported proliferation or erosions in DPTH. Conclusion: Sclerosis in the DPTH is the most frequent radiographic alteration in patients with RA. However, it cannot be considered a pathognomonic finding of that condition, the-refore new studies with a more solid methodological structure are needed to clarify this association. Finally, proliferation, erosion or resorption on the DPTH are not typical radiographic findings in subjects with RA.


Subject(s)
Arthritis, Rheumatoid , Finger Phalanges , Arthritis , Synovitis , Joints
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